Road Trip can calculate the maximum distance you can travel on a single tank of fuel based on the size of your tank and your average fuel efficiency. In order for Road Trip to make this calculation you must first enter your car's fuel tank capacity, by selecting Preference > Advanced > Tank Capacity
Advanced Preferences Screen
Once the Tank Capacity has been set, Road Trip's Statistics page will calculate the maximum distance per tank based on your average fuel efficiency:
Statistics Screen with Maximum Distance per Tank